Molecule Details
InChIKeyJAQUASYNZVUNQP-USXIJHARSA-N
Compound NameLevorphanol
Canonical SMILESCN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc13
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL8.9
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00854
Drug NameLevorphanol
CAS Number77-07-6
Groups approved
ATC Codes nan
DescriptionA narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.

Categories: Alkaloids Analgesics Central Nervous System Agents Central Nervous System Depressants Heterocyclic Compounds, Fused-Ring Morphinans Narcotics Opiate Alkaloids Opioid Agonist Opioids Peripheral Nervous System Agents Phenanthrenes Sensory System Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
Cross-references: BindingDB: 82427 ChEBI: 6444 CHEMBL592 ChemSpider: 16736212 C08014 D08123 PharmGKB: PA164744368 PubChem:5359272 PubChem:46506558 RxCUI: 6378 Therapeutic Targets Database: DAP000268 Wikipedia: Levorphanol ZINC: ZINC000003812984
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P35372 OPRM1 Homo sapiens Human PF00001 9.7 Ki ChEMBL;BindingDB
P41145 OPRK1 Homo sapiens Human PF00001 8.6 Ki ChEMBL;BindingDB
P41143 OPRD1 Homo sapiens Human PF00001 8.4 Ki ChEMBL;BindingDB
DrugBank Target Actions (3)
Target Gene Target Name Action Type
P35372 OPRM1 Mu-type opioid receptor agonist targets
P41143 OPRD1 Delta-type opioid receptor agonist targets
P41145 OPRK1 Kappa-type opioid receptor agonist targets