Molecule Details
| InChIKey | JAQUASYNZVUNQP-PVAVHDDUSA-N |
|---|---|
| Compound Name | Dextrorphan |
| Canonical SMILES | CN1CC[C@@]23CCCC[C@@H]2[C@@H]1Cc1ccc(O)cc13 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 8 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.65 |
| Source | ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB14682 |
|---|---|
| Drug Name | Dextrorphan |
| CAS Number | 125-73-5 |
| Groups | experimental |
| ATC Codes | nan |
| Description | nan |
Categories: Alkaloids Central Nervous System Agents Compounds used in a research, industrial, or household setting Excitatory Amino Acid Agents Excitatory Amino Acid Antagonists Heterocyclic Compounds, Fused-Ring Morphinans Neuroprotective Agents Neurotransmitter Agents Opiate Alkaloids Phenanthrenes Protective Agents
Cross-references: BindingDB: 50001000 ChEBI: 29133 CHEMBL1254766 ChemSpider: 10489895 Wikipedia: Dextrorphan ZINC: ZINC000001280092
Target Activities (8)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O15399 | GRIN2D | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.7 | Ki | ChEMBL |
| O60391 | GRIN3B | Homo sapiens | Human | PF00060 PF10613 | 6.7 | Ki | ChEMBL |
| Q12879 | GRIN2A | Homo sapiens | Human | PF01094 PF00060 PF10613 PF10565 | 6.7 | Ki | ChEMBL |
| Q14957 | GRIN2C | Homo sapiens | Human | PF01094 PF00060 PF10613 PF10565 | 6.7 | Ki | ChEMBL |
| Q8TCU5 | GRIN3A | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.7 | Ki | ChEMBL |
| Q99720 | SIGMAR1 | Homo sapiens | Human | PF04622 | 6.7 | IC50 | ChEMBL |
| Q05586 | GRIN1 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.6 | IC50 | ChEMBL |
| Q13224 | GRIN2B | Homo sapiens | Human | PF01094 PF00060 PF10613 PF10565 | 6.6 | IC50 | ChEMBL |