Molecule Details
| InChIKey | IZRPKIZLIFYYKR-UHFFFAOYSA-N |
|---|---|
| Compound Name | Phenyltoloxamine |
| Canonical SMILES | CN(C)CCOc1ccccc1Cc1ccccc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.91 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB11160 |
|---|---|
| Drug Name | Phenyltoloxamine |
| CAS Number | 92-12-6 |
| Groups | approved |
| ATC Codes | nan |
| Description | Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltolox... |
Categories: Benzene Derivatives
Cross-references: BindingDB: 50151046 ChEBI: 135047 CHEMBL186720 ChemSpider: 6810 Drugs Product Database (DPD): 6044 PubChem:7077 PubChem:347827928 RxCUI: 33408 Wikipedia: Phenyltoloxamine ZINC: ZINC000000001931
Target Activities (3)
DrugBank Target Actions (5)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P14416 | DRD2 | D(2) dopamine receptor | inhibitor | targets |
| P21728 | DRD1 | D(1A) dopamine receptor | inhibitor | targets |
| P21917 | DRD4 | D(4) dopamine receptor | inhibitor | targets |
| P21918 | DRD5 | D(1B) dopamine receptor | inhibitor | targets |
| P70174 | P70174 | Histamine H1 receptor | inverse agonist | targets |