Molecule Details
| InChIKey | IZGDUNLRMAOQTD-UHFFFAOYSA-N |
|---|---|
| Compound Name | N-[4-[2-(hydroxyamino)-2-oxoethyl]-1,3-thiazol-2-yl]-1-phenyl-4H-quinoline-4-carboxamide |
| Canonical SMILES | O=C(Cc1csc(NC(=O)C2C=CN(c3ccccc3)c3ccccc32)n1)NO |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.34 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P54750 | PDE1A | Homo sapiens | Human | PF00233 PF08499 | 6.4 | IC50 | ChEMBL |
| Q01064 | PDE1B | Homo sapiens | Human | PF00233 PF08499 | 6.4 | IC50 | ChEMBL;BindingDB |
| Q14123 | PDE1C | Homo sapiens | Human | PF00233 PF08499 | 6.4 | IC50 | ChEMBL |
| O76074 | PDE5A | Homo sapiens | Human | PF01590 PF00233 | 6.1 | IC50 | ChEMBL;BindingDB |