InChIKey	IYIKLHRQXLHMJQ-UHFFFAOYSA-N
Compound Name	Amiodarone
Canonical SMILES	CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	18
Pfam Stratification	Cross-Family
Avg pChEMBL	6.61
Source	ChEMBL;BindingDB

DrugBank ID	DB01118
Drug Name	Amiodarone
CAS Number	1951-25-3
Groups	approved investigational
ATC Codes	C01BD01
Description	Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings.[A36817] Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ab...

---

Categories: Agents Causing Muscle Toxicity Agents causing hyperkalemia Antiarrhythmic agents Antiarrhythmics, Class III BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates BSEP/ABCB11 Substrates with a Narrow Therapeutic Index Benzofurans Bradycardia-Causing Agents Calcium Channel Blockers Cardiac Therapy Cardiovascular Agents Cytochrome P-450 CYP1A1 Substrates Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strong) Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (moderate) Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (weak) Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors (strong) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates (strength unknown) Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs causing inadvertant photosensitivity Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Highest Risk QTc-Prolonging Agents Hypotensive Agents Membrane Transport Modulators Narrow Therapeutic Index Drugs OCT2 Inhibitors P-glycoprotein inducers P-glycoprotein inhibitors Photosensitizing Agents Potassium Channel Blockers QTc Prolonging Agents Sodium Channel Blockers Vasodilating Agents alpha-Galactosidase, antagonists & inhibitors

---

Cross-references: BindingDB: 18957 ChEBI: 2663 CHEMBL633 ChemSpider: 2072 Drugs Product Database (DPD): 1400 Guide to Pharmacology: 2566 IUPHAR: 2566 C06823 D02910 PDB: BBI PharmGKB: PA448383 PubChem:2157 PubChem:46507387 RxCUI: 703 Therapeutic Targets Database: DAP000496 Wikipedia: Amiodarone ZINC: ZINC000003830212