Molecule Details
| InChIKey | IYFJURORHSNANJ-UHFFFAOYSA-N |
|---|---|
| Compound Name | 5'-[3-(4-Fluorophenyl)-1-methylpyrazol-5-yl]-2-(2,2,2-trifluoroethyl)spiro[1,2,5-thiadiazolidine-4,13'-tricyclo[8.2.1.03,8]trideca-3(8),4,6-triene] 1,1-dioxide |
| Canonical SMILES | Cn1nc(-c2ccc(F)cc2)cc1-c1ccc2c(c1)CC1CCC(C2)C12CN(CC(F)(F)F)S(=O)(=O)N2 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 6 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 8.78 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (6)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P49810 | PSEN2 | Homo sapiens | Human | PF01080 | 8.8 | IC50 | ChEMBL |
| Q8WW43 | APH1B | Homo sapiens | Human | PF06105 | 8.8 | IC50 | ChEMBL |
| Q92542 | NCSTN | Homo sapiens | Human | PF18266 PF05450 | 8.8 | IC50 | ChEMBL |
| Q96BI3 | APH1A | Homo sapiens | Human | PF06105 | 8.8 | IC50 | ChEMBL |
| Q9NZ42 | PSENEN | Homo sapiens | Human | PF10251 | 8.8 | IC50 | ChEMBL |
| P49768 | PSEN1 | Homo sapiens | Human | PF01080 | 8.8 | IC50 | ChEMBL;BindingDB |