Molecule Details
| InChIKey | IWKXDMQDITUYRK-KUBHLMPHSA-N |
|---|---|
| Compound Name | Forodesine |
| Canonical SMILES | O=c1[nH]cnc2c([C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)c[nH]c12 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.76 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB06185 |
|---|---|
| Drug Name | Forodesine |
| CAS Number | 209799-67-7 |
| Groups | investigational |
| ATC Codes | nan |
| Description | Forodesine is a highly potent, orally active, rationally designed PNP inhibitor that has shown activity in preclinical studies with malignant cells and clinical utility against T-cell acute lymphoblastic leukemia and cutaneous T-cell lymphoma. Additional preliminary findings support its use for the ... |
Categories: Heterocyclic Compounds, Fused-Ring Nucleic Acids, Nucleotides, and Nucleosides Nucleosides Purine-Nucleoside Phosphorylase, antagonists & inhibitors Purines Pyrimidines
Cross-references: BindingDB: 50195587 ChEBI: 43362 CHEMBL218291 ChemSpider: 392417 D06596 PDB: IMH PubChem:444499 Wikipedia: Forodesine ZINC: ZINC000013492899
Target Activities (2)
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P00491 | PNP | Purine nucleoside phosphorylase | inhibitor | targets |