Molecule Details
| InChIKey | IVVNZDGDKPTYHK-UHFFFAOYSA-N |
|---|---|
| Compound Name | Pinacidil anhydrous |
| Canonical SMILES | CC(N=C(NC#N)Nc1ccncc1)C(C)(C)C |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.5 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB06762 |
|---|---|
| Drug Name | Pinacidil |
| CAS Number | 60560-33-0 |
| Groups | approved |
| ATC Codes | C02DG01 C02LX01 |
| Description | Pinacidil is a cyanoguanidine drug that acts by opening ATP-sensitive potassium channels, leading to peripheral vasodilatation of arterioles and decreasing peripheral vascular resistance. The above processes result in reduced blood pressure. This drug has been discontinued by the FDA. |
Categories: Amidines Antihypertensive Agents Arteriolar Smooth Muscle, Agents Acting On Cardiovascular Agents Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Guanidine Derivatives Guanidines Membrane Transport Modulators Potassium Channel Opener Vasodilating Agents
Cross-references: BindingDB: 50240750 ChEBI: 91706 CHEMBL1159 ChemSpider: 4660 RxCUI: 33717 Wikipedia: Pinacidil
Target Activities (2)
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P08684 | CYP3A4 | Cytochrome P450 3A4 | substrate | enzymes |