Molecule Details
InChIKeyIUWWRSQCDUQDEZ-QYMSDJBWSA-N
Compound Name4-({5-chloro-4-[(cis-4-hydroxy-4-methylcyclohexyl)oxy]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)-N,N-dimethyl-3-{[(2R)-1,1,1-trifluoropropan-2-yl]oxy}benzamide
Canonical SMILESC[C@@H](Oc1cc(C(=O)N(C)C)ccc1Nc1nc(OC2CCC(C)(O)CC2)c2c(Cl)c[nH]c2n1)C(F)(F)F
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)9
Pfam Stratification Cross-Family
Avg pChEMBL9.91
SourceBindingDB
2D Structure
2D structure
Activity Profile
Target Activities (9)
Target Gene Organism Category Pfam pChEMBL Type Source
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 12.0 IC50 BindingDB
P45983 MAPK8 Homo sapiens Human PF00069 10.5 IC50 BindingDB
P45984 MAPK9 Homo sapiens Human PF00069 10.2 IC50 BindingDB
O43781 DYRK3 Homo sapiens Human PF00069 10.0 IC50 BindingDB
P53779 MAPK10 Homo sapiens Human PF00069 10.0 IC50 BindingDB
Q9BXA7 TSSK1B Homo sapiens Human PF00069 9.7 IC50 BindingDB
P49760 CLK2 Homo sapiens Human PF00069 9.6 IC50 BindingDB
P29376 LTK Homo sapiens Human PF12810 PF07714 9.2 IC50 BindingDB
P33981 TTK Homo sapiens Human PF00069 8.0 IC50 BindingDB