Molecule Details
InChIKeyIUEBPIPDFMCSTP-UHFFFAOYSA-N
Compound Name8-Thia-3,5,10,12-tetrazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene-6,13-diamine
Canonical SMILESNc1ncnc2c1sc1ncnc(N)c12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)29
Pfam Stratification Cross-Family
Avg pChEMBL6.44
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (29)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.9 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 7.4 Ki ChEMBL
P48730 CSNK1D Homo sapiens Human PF00069 7.3 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 7.1 Ki ChEMBL
Q9HBY8 SGK2 Homo sapiens Human PF00069 PF00433 6.8 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.7 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.7 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 6.6 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.5 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.5 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.4 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 6.4 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 6.4 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.3 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 6.3 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 6.3 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.2 Ki ChEMBL
O00311 CDC7 Homo sapiens Human PF00069 6.1 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.1 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.1 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.1 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q86V86 PIM3 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P48729 CSNK1A1 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.0 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 6.0 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 6.0 Ki ChEMBL