1-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-(2-methylphenyl)urea

InChIKey	`ISVHLTLEHRZKJC-UHFFFAOYSA-N`
Compound Name	1-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-(2-methylphenyl)urea
Canonical SMILES	`Cc1ccccc1NC(=O)Nc1ccc(-c2coc3ncnc(N)c23)cc1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	19
Pfam Stratification	Cross-Family
Avg pChEMBL	6.71
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P36888	FLT3	Homo sapiens	Human	PF00047 PF07714	8.3	Ki	ChEMBL
Q96GD4	AURKB	Homo sapiens	Human	PF00069	7.8	Ki	ChEMBL
Q9HCP0	CSNK1G1	Homo sapiens	Human	PF12605 PF00069	7.7	Ki	ChEMBL
Q9Y4K4	MAP4K5	Homo sapiens	Human	PF00780 PF00069	7.6	Ki	ChEMBL
O14965	AURKA	Homo sapiens	Human	PF00069	7.2	Ki	ChEMBL
P17948	FLT1	Homo sapiens	Human	PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	6.8	Ki	ChEMBL
P51451	BLK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.7	Ki	ChEMBL
P07948	LYN	Homo sapiens	Human	PF07714 PF00017 PF00018	6.6	Ki	ChEMBL
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	6.5	Ki	ChEMBL
Q9H2X6	HIPK2	Homo sapiens	Human	PF00069	6.5	Ki	ChEMBL
Q9HBH9	MKNK2	Homo sapiens	Human	PF00069	6.5	Ki	ChEMBL
P42685	FRK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.4	Ki	ChEMBL
O00444	PLK4	Homo sapiens	Human	PF00069 PF18190 PF18409	6.3	Ki	ChEMBL
Q12851	MAP4K2	Homo sapiens	Human	PF00780 PF00069	6.3	Ki	ChEMBL
Q8NE63	HIPK4	Homo sapiens	Human	PF00069	6.2	Ki	ChEMBL
P06239	LCK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.1	Ki	ChEMBL
P78368	CSNK1G2	Homo sapiens	Human	PF12605 PF00069	6.0	Ki	ChEMBL
Q16288	NTRK3	Homo sapiens	Human	PF07679 PF00047 PF13855 PF16920 PF01462 PF07714	6.0	Ki	ChEMBL
Q8N4C8	MINK1	Homo sapiens	Human	PF00780 PF00069	6.0	Ki	ChEMBL