Molecule Details
InChIKeyISPBCAXOSOLFME-UHFFFAOYSA-N
Compound NameLdc1267
Canonical SMILESCCOc1cn(-c2ccc(F)cc2C)nc1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)11
Pfam Stratification Cross-Family
Avg pChEMBL7.33
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (11)
Target Gene Organism Category Pfam pChEMBL Type Source
Q06418 TYRO3 Homo sapiens Human PF00041 PF07679 PF07714 8.3 IC50 ChEMBL;BindingDB
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 8.0 IC50 ChEMBL;BindingDB
P08581 MET Homo sapiens Human PF07714 PF01437 PF01403 PF01833 7.7 IC50 ChEMBL
O14965 AURKA Homo sapiens Human PF00069 7.4 IC50 ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 7.4 IC50 ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 7.3 IC50 ChEMBL
Q12866 MERTK Homo sapiens Human PF00041 PF00047 PF13927 PF07714 7.2 IC50 ChEMBL;BindingDB
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 7.0 Kd ChEMBL
Q13163 MAP2K5 Homo sapiens Human PF00564 PF00069 6.9 Kd ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.8 Kd ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.6 IC50 ChEMBL