Pyrrolo[3,2,1-jk][1,4]benzodiazepine, 7-(2,5-dihydro-4-imidazo[1,2-a]pyridin-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-1,2,3,4-tetrahydro-2-(4-morpholinylcarbonyl)-(9CI)

InChIKey	`INJUVNWOFHYUIN-UHFFFAOYSA-N`
Compound Name	Pyrrolo[3,2,1-jk][1,4]benzodiazepine, 7-(2,5-dihydro-4-imidazo[1,2-a]pyridin-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-1,2,3,4-tetrahydro-2-(4-morpholinylcarbonyl)-(9CI)
Canonical SMILES	`O=C1NC(=O)C(c2cnc3ccccn23)=C1c1cn2c3c(cccc13)CN(C(=O)N1CCOCC1)CC2`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	9
Pfam Stratification	Cross-Family
Avg pChEMBL	6.87
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P49840	GSK3A	Homo sapiens	Human	PF00069	8.9	IC50	ChEMBL
P49841	GSK3B	Homo sapiens	Human	PF00069	8.9	IC50	ChEMBL;BindingDB
P24941	CDK2	Homo sapiens	Human	PF00069	6.5	Ki	ChEMBL
Q9HAZ1	CLK4	Homo sapiens	Human	PF00069	6.5	Ki	ChEMBL
P11309	PIM1	Homo sapiens	Human	PF00069	6.1	Ki	ChEMBL
P49760	CLK2	Homo sapiens	Human	PF00069	6.1	Ki	ChEMBL
P06239	LCK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.0	Ki	ChEMBL
P06493	CDK1	Homo sapiens	Human	PF00069	6.0	Ki	ChEMBL
P11802	CDK4	Homo sapiens	Human	PF00069	Clinical	TTD_MultiTarget	TTD_MultiTarget