Molecule Details
| InChIKey | IMYZQPCYWPFTAG-UHFFFAOYSA-N |
|---|---|
| Compound Name | Mecamylamine |
| Canonical SMILES | CNC1(C)C2CCC(C2)C1(C)C |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.43 |
| Source | ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00657 |
|---|---|
| Drug Name | Mecamylamine |
| CAS Number | 60-40-2 |
| Groups | approved investigational |
| ATC Codes | C02BB01 |
| Description | A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool. |
Categories: Agents that produce neuromuscular block (indirect) Antiadrenergic Agents, Ganglion-Blocking Anticholinergic Agents Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension Autonomic Agents Autonomic Ganglionic Blocker Bridged-Ring Compounds Cardiovascular Agents Cholinergic Agents Decreased Autonomic Ganglionic Activity Drugs that are Mainly Renally Excreted Ganglion Blockers Hypotensive Agents Neurotransmitter Agents Nicotinic Antagonists Norbornanes Peripheral Nervous System Agents Secondary and Tertiary Amines
Cross-references: BindingDB: 50061565 ChEBI: 6706 CHEMBL267936 ChemSpider: 3892 Guide to Pharmacology: 3990 IUPHAR: 3990 C07511 PharmGKB: PA450334 PubChem:4032 PubChem:46508607 RxCUI: 6673 Therapeutic Targets Database: DAP000027 Wikipedia: Mecamylamine
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P30926 | CHRNB4 | Homo sapiens | Human | PF02931 PF02932 | 6.6 | IC50 | ChEMBL |
| P32297 | CHRNA3 | Homo sapiens | Human | PF02931 PF02932 | 6.5 | IC50 | ChEMBL |
| P17787 | CHRNB2 | Homo sapiens | Human | PF02931 PF02932 | 6.4 | IC50 | ChEMBL |
| P43681 | CHRNA4 | Homo sapiens | Human | PF02931 PF02932 | 6.2 | IC50 | ChEMBL |
DrugBank Target Actions (4)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P17787 | CHRNB2 | Neuronal acetylcholine receptor subunit beta-2 | antagonist | targets |
| P36544 | CHRNA7 | Neuronal acetylcholine receptor subunit alpha-7 | antagonist | targets |
| P43681 | CHRNA4 | Neuronal acetylcholine receptor subunit alpha-4 | antagonist | targets |
| Q15822 | CHRNA2 | Neuronal acetylcholine receptor subunit alpha-2 | antagonist | targets |