InChIKey	IKENVDNFQMCRTR-UHFFFAOYSA-N
Compound Name	Conivaptan
Canonical SMILES	Cc1nc2c([nH]1)-c1ccccc1N(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)CC2
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Homologous
Avg pChEMBL	8.82
Source	ChEMBL;BindingDB

DrugBank ID	DB00872
Drug Name	Conivaptan
CAS Number	210101-16-9
Groups	approved
ATC Codes	C03XA02
Description	Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2).

---

Categories: Antidiuretic Hormone Receptor Antagonists Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strong) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Diuretics Heterocyclic Compounds, Fused-Ring Hypotensive Agents Narrow Therapeutic Index Drugs Natriuretic Agents P-glycoprotein inhibitors

---

Cross-references: BindingDB: 85095 ChEBI: 681850 CHEMBL1755 ChemSpider: 133239 Guide to Pharmacology: 2203 IUPHAR: 2203 D07748 PharmGKB: PA164742939 PubChem:151171 PubChem:46504533 RxCUI: 302285 Therapeutic Targets Database: DNC001525 Wikipedia: Conivaptan ZINC: ZINC000012503187