InChIKey	IKBKZGMPCYNSLU-RGVLZGJSSA-N
Compound Name	Tegaserod
Canonical SMILES	CCCCCNC(=N)N/N=C/c1c[nH]c2ccc(OC)cc12
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	13
Pfam Stratification	Cross-Family
Avg pChEMBL	6.95
Source	ChEMBL

DrugBank ID	DB01079
Drug Name	Tegaserod
CAS Number	145158-71-0
Groups	approved withdrawn
ATC Codes	A06AX06
Description	Novartis' brand name Zelnorm (tegaserod) had originally received approval from the US FDA in 2002 for the treatment of irritable bowel syndrome with constipation (IBS-C).[L5918,F4229] It was, however, voluntarily withdrawn from widespread use in the US market in 2007 after concerns arose over the po...

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Categories: Alimentary Tract and Metabolism Antidepressive Agents BCRP/ABCG2 Substrates Central Nervous System Depressants Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (weak) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (weak) Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs for Constipation Gastrointestinal Agents Heterocyclic Compounds, Fused-Ring Laxatives P-glycoprotein substrates Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin 4 Receptor Agonists Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin 5-HT2C Receptor Antagonists Serotonin Agents Serotonin Receptor Antagonists Serotonin-4 Receptor Agonist

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Cross-references: BindingDB: 50248157 ChEBI: 51043 CHEMBL76370 ChemSpider: 10609889 D06056 PDB: A1IVL PharmGKB: PA130413154 PubChem:5362436 PubChem:46506519 RxCUI: 139778 Therapeutic Targets Database: DAP001526 Wikipedia: Tegaserod ZINC: ZINC000001545565