Molecule Details
InChIKeyIJNGXROUMFEKDB-UHFFFAOYSA-N
Compound Name2-[2-amino-7-[7-(1-benzothiophen-2-yl)-1H-indazol-5-yl]pyrrolo[3,2-d]pyrimidin-5-yl]acetamide
Canonical SMILESNC(=O)Cn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)39
Pfam Stratification Cross-Family
Avg pChEMBL6.64
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (39)
Target Gene Organism Category Pfam pChEMBL Type Source
O15530 PDPK1 Homo sapiens Human PF14593 PF00069 8.1 Ki ChEMBL
P49137 MAPKAPK2 Homo sapiens Human PF00069 7.6 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.6 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 7.4 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 7.4 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 7.3 Ki ChEMBL
P41743 PRKCI Homo sapiens Human PF00130 PF00564 PF00069 PF00433 7.2 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 7.1 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 7.1 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 7.0 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 7.0 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 7.0 Ki ChEMBL
O00311 CDC7 Homo sapiens Human PF00069 6.9 Ki ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 6.9 Ki ChEMBL
Q05513 PRKCZ Homo sapiens Human PF00130 PF00564 PF00069 PF00433 6.8 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.7 Ki ChEMBL
P43405 SYK Homo sapiens Human PF07714 PF00017 6.7 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.7 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 6.6 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 6.5 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.4 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.4 Ki ChEMBL
Q13976 PRKG1 Homo sapiens Human PF00027 PF16808 PF00069 6.4 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.3 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 6.3 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 6.2 Ki ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.2 Ki ChEMBL
Q8IW41 MAPKAPK5 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.2 Ki ChEMBL
O15264 MAPK13 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q13237 PRKG2 Homo sapiens Human PF00027 PF00069 6.1 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.1 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 6.0 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.0 Ki ChEMBL
P04626 ERBB2 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.0 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q14289 PTK2B Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 6.0 Ki ChEMBL