InChIKey	IIXWYSCJSQVBQM-LLVKDONJSA-N
Compound Name	Lorlatinib
Canonical SMILES	C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	18
Pfam Stratification	Cross-Family
Avg pChEMBL	8.02
Source	ChEMBL;BindingDB

DrugBank ID	DB12130
Drug Name	Lorlatinib
CAS Number	1454846-35-5
Groups	approved investigational
ATC Codes	L01ED05
Description	Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer[L39905] which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with prev...

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Categories: Amides Amines Anaplastic lymphoma kinase (ALK) inhibitors Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Inhibitors Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Kinase Inhibitor Lactams MATE 1 Inhibitors MATE inhibitors OAT3/SLC22A8 Inhibitors Organic Cation Transporter 1 Inhibitors P-glycoprotein inducers Protein Kinase Inhibitors Pyridines ROS1 tyrosine kinase inhibitors Tyrosine Kinase Inhibitors UGT1A3 substrates

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Cross-references: BindingDB: 50018830 ChEBI: 143117 CHEMBL3286830 ChemSpider: 32813339 Drugs Product Database (DPD): 23119 PDB: 5P8 PubChem:71731823 PubChem:347828429 RxCUI: 2103164 Wikipedia: Lorlatinib ZINC: ZINC000098208524