Molecule Details
InChIKeyIFXJYXJVOYKBDP-UHFFFAOYSA-N
Compound Name4-(3-ethyl-7-fluoro-2,3-dimethylindol-5-yl)-N-[5-[(4-ethylpiperazin-1-yl)methyl]-2-pyridinyl]-5-fluoropyrimidin-2-amine
Canonical SMILESCCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5c(c4)C(C)(CC)C(C)=N5)n3)nc2)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)8
Pfam Stratification Cross-Family
Avg pChEMBL6.93
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (8)
Target Gene Organism Category Pfam pChEMBL Type Source
Q00534 CDK6 Homo sapiens Human PF00069 7.9 IC50 ChEMBL;BindingDB
P30281 CCND3 Homo sapiens Human PF02984 PF00134 7.8 IC50 ChEMBL
P11802 CDK4 Homo sapiens Human PF00069 7.5 IC50 ChEMBL;BindingDB
P24385 CCND1 Homo sapiens Human PF02984 PF00134 7.5 IC50 ChEMBL
O96020 CCNE2 Homo sapiens Human PF02984 PF00134 6.4 IC50 ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.4 IC50 ChEMBL;BindingDB
P06493 CDK1 Homo sapiens Human PF00069 6.0 IC50 ChEMBL;BindingDB
P20248 CCNA2 Homo sapiens Human PF02984 PF00134 PF16500 6.0 IC50 ChEMBL