Molecule Details
| InChIKey | IEJXVRYNEISIKR-UHFFFAOYSA-N |
|---|---|
| Compound Name | Apraclonidine |
| Canonical SMILES | Nc1cc(Cl)c(N=C2NCCN2)c(Cl)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 6 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.45 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00964 |
|---|---|
| Drug Name | Apraclonidine |
| CAS Number | 66711-21-5 |
| Groups | approved |
| ATC Codes | S01EA03 |
| Description | Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist. |
Categories: Adrenergic Agents Adrenergic Agonists Adrenergic alpha-1 Receptor Agonists Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists Antiglaucoma Preparations and Miotics EENT Drugs, Miscellaneous Hypotensive Agents Imidazoles Imidazolines Neurotransmitter Agents Ophthalmics Ophthalmologicals Sensory Organs Sympathomimetics in Glaucoma Therapy
Cross-references: BindingDB: 81926 ChEBI: 2788 CHEMBL647 ChemSpider: 2130 Drugs Product Database (DPD): 11372 C07668 PharmGKB: PA164748866 PubChem:2216 PubChem:46505614 RxCUI: 14845 Therapeutic Targets Database: DAP000236 Wikipedia: Apraclonidine ZINC: ZINC000000020231
Target Activities (6)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P08913 | ADRA2A | Homo sapiens | Human | PF00001 | 8.4 | Ki | ChEMBL;BindingDB |
| P18089 | ADRA2B | Homo sapiens | Human | PF00001 | 8.3 | Ki | ChEMBL;BindingDB |
| P18825 | ADRA2C | Homo sapiens | Human | PF00001 | 7.7 | Ki | ChEMBL;BindingDB |
| P25100 | ADRA1D | Homo sapiens | Human | PF00001 | 6.8 | Ki | ChEMBL |
| P35348 | ADRA1A | Homo sapiens | Human | PF00001 | 6.8 | Ki | ChEMBL |
| P35368 | ADRA1B | Homo sapiens | Human | PF00001 | 6.8 | Ki | ChEMBL |