Molecule Details
| InChIKey | IEDCMMDQOKHGLE-OWOJBTEDSA-N |
|---|---|
| Compound Name | 3-[1-[(E)-4-hydroxybut-2-enoyl]azetidin-3-yl]-1-[4-(trifluoromethoxy)phenyl]pyrazolo[3,4-b]pyridine-4-carbonitrile |
| Canonical SMILES | N#Cc1ccnc2c1c(C1CN(C(=O)/C=C/CO)C1)nn2-c1ccc(OC(F)(F)F)cc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.7 |
| Source | BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q15561 | TEAD4 | Homo sapiens | Human | PF01285 PF17725 | 8.2 | IC50 | BindingDB |
| P28347 | TEAD1 | Homo sapiens | Human | PF01285 PF17725 | 7.7 | IC50 | BindingDB |
| Q99594 | TEAD3 | Homo sapiens | Human | PF01285 PF17725 | 7.7 | IC50 | BindingDB |
| Q15562 | TEAD2 | Homo sapiens | Human | PF01285 PF17725 | 7.2 | IC50 | BindingDB |