Molecule Details
InChIKeyIDKAKZRYYDCJDU-HBMMIIHUSA-N
Canonical SMILESCC(C)(C)C[C@@H]1N[C@@H](C(=O)N[C@H]2CC[C@H](O)CC2)[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Cross-Family
Avg pChEMBL8.98
SourceChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB12541
Drug NameSAR-405838
CAS Number1303607-60-4
Groups investigational
ATC Codes nan
DescriptionSAR405838 has been used in trials studying the treatment of Neoplasm Malignant.

Categories: Heterocyclic Compounds, Fused-Ring P-glycoprotein substrates
Cross-references: BindingDB: 50433561 CHEMBL2381408 ChemSpider: 30811498 PDB: 7HC PubChem:53476877 PubChem:347828767 ZINC: ZINC000145424989
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
Q00987 MDM2 Homo sapiens Human PF02201 PF13920 PF00641 9.1 Ki ChEMBL
P04637 TP53 Homo sapiens Human PF00870 PF08563 PF07710 PF18521 8.9 Ki ChEMBL
DrugBank Target Actions (2)
Target Gene Target Name Action Type
P04637 TP53 Cellular tumor antigen p53 modulator targets
P08183 ABCB1 ATP-dependent translocase ABCB1 substrate transporters