Molecule Details
| InChIKey | IBCXZJCWDGCXQT-UHFFFAOYSA-N |
|---|---|
| Compound Name | Ly-364947 |
| Canonical SMILES | c1ccc(-c2n[nH]cc2-c2ccnc3ccccc23)nc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.78 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB03921 |
|---|---|
| Drug Name | 4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline |
| CAS Number | nan |
| Groups | experimental |
| ATC Codes | nan |
| Description | nan |
Cross-references: BindingDB: 21492 ChEBI: 91198 CHEMBL261454 ChemSpider: 394909 PDB: PY1 PubChem:447966 PubChem:46505424 ZINC: ZINC000015894680
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P36897 | TGFBR1 | Homo sapiens | Human | PF01064 PF00069 PF08515 | 7.3 | IC50 | ChEMBL;BindingDB |
| P37023 | ACVRL1 | Homo sapiens | Human | PF07714 PF08515 | 7.3 | IC50 | BindingDB |
| P37173 | TGFBR2 | Homo sapiens | Human | PF08917 PF07714 | 6.4 | IC50 | ChEMBL;BindingDB |
| Q16539 | MAPK14 | Homo sapiens | Human | PF00069 | 6.1 | IC50 | ChEMBL;BindingDB |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P36897 | TGFBR1 | TGF-beta receptor type-1 | inhibitor | targets |