Molecule Details
InChIKeyIAPISFUJUUDVNW-UHFFFAOYSA-N
Compound Name4-((7'-oxo-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'-yl)amino)benzenesulfonamide
Canonical SMILESNS(=O)(=O)c1ccc(Nc2ncc3cc4n(c3n2)C2(CCCCC2)CC(=O)N4)cc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)15
Pfam Stratification Cross-Family
Avg pChEMBL8.06
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (15)
Target Gene Organism Category Pfam pChEMBL Type Source
P20248 CCNA2 Homo sapiens Human PF02984 PF00134 PF16500 9.4 IC50 ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 9.3 IC50 ChEMBL;BindingDB
Q15078 CDK5R1 Homo sapiens Human PF03261 8.9 IC50 ChEMBL;BindingDB
Q00535 CDK5 Homo sapiens Human PF00069 8.9 IC50 ChEMBL;BindingDB
P24864 CCNE1 Homo sapiens Human PF02984 PF00134 8.6 IC50 ChEMBL;BindingDB
Q00526 CDK3 Homo sapiens Human PF00069 8.6 IC50 ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 8.4 IC50 ChEMBL;BindingDB
O60563 CCNT1 Homo sapiens Human PF00134 PF21797 8.3 IC50 ChEMBL;BindingDB
P50750 CDK9 Homo sapiens Human PF00069 8.3 IC50 ChEMBL
P11802 CDK4 Homo sapiens Human PF00069 7.4 IC50 ChEMBL;BindingDB
P24385 CCND1 Homo sapiens Human PF02984 PF00134 7.4 IC50 ChEMBL
P30281 CCND3 Homo sapiens Human PF02984 PF00134 7.0 IC50 ChEMBL
Q00534 CDK6 Homo sapiens Human PF00069 7.0 IC50 ChEMBL;BindingDB
P50613 CDK7 Homo sapiens Human PF00069 6.7 IC50 ChEMBL;BindingDB
P51946 CCNH Homo sapiens Human PF16899 PF00134 6.7 IC50 BindingDB