InChIKey	IAKHMKGGTNLKSZ-INIZCTEOSA-N
Compound Name	Colchicine
Canonical SMILES	COc1cc2c(c(OC)c1OC)-c1ccc(OC)c(=O)cc1[C@@H](NC(C)=O)CC2
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	16
Pfam Stratification	Cross-Family
Avg pChEMBL	6.73
Source	ChEMBL;BindingDB

DrugBank ID	DB01394
Drug Name	Colchicine
CAS Number	64-86-8
Groups	approved investigational
ATC Codes	M04AC51 M04AC01
Description	Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus."[A183611] Its use was first approved by the FDA in 1961.[L8192] Colchicine is used in the treatment of gout flares and Familial Mediterranean fever,[L8138] and prevent...

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Categories: Agents Causing Muscle Toxicity Alkaloids Antigout Preparations Antimitotic Agents Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) Cytochrome P-450 CYP2E1 Inducers Cytochrome P-450 CYP2E1 Inducers (strength unknown) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs that are Mainly Renally Excreted Experimental Unapproved Treatments for COVID-19 Mitosis Modulators Musculo-Skeletal System P-glycoprotein inducers P-glycoprotein substrates Preparations With No Effect on Uric Acid Metabolism Tubulin Modulators

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Cross-references: BindingDB: 50014846 ChEBI: 27882 CHEMBL107 ChemSpider: 5933 Drugs Product Database (DPD): 6760 Guide to Pharmacology: 2367 IUPHAR: 2367 C07592 D00570 PDB: LOC PharmGKB: PA449092 PubChem:2833 PubChem:46505639 RxCUI: 2683 Therapeutic Targets Database: DAP001254 Wikipedia: Colchicine ZINC: ZINC000000621853