4-amino-N-[4-[(3,5-dimethylphenyl)carbamoylamino]phenyl]thieno[2,3-d]pyrimidine-5-carboxamide

InChIKey	`IAKGNUWZPSPEKU-UHFFFAOYSA-N`
Compound Name	4-amino-N-[4-[(3,5-dimethylphenyl)carbamoylamino]phenyl]thieno[2,3-d]pyrimidine-5-carboxamide
Canonical SMILES	`Cc1cc(C)cc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	19
Pfam Stratification	Cross-Family
Avg pChEMBL	7.02
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
O96017	CHEK2	Homo sapiens	Human	PF00498 PF00069	8.8	Ki	ChEMBL
O14965	AURKA	Homo sapiens	Human	PF00069	8.6	Ki	ChEMBL
O00444	PLK4	Homo sapiens	Human	PF00069 PF18190 PF18409	7.7	Ki	ChEMBL
P30530	AXL	Homo sapiens	Human	PF00041 PF13927 PF07714	7.3	Ki	ChEMBL
O95819	MAP4K4	Homo sapiens	Human	PF00780 PF00069	7.2	Ki	ChEMBL
P51451	BLK	Homo sapiens	Human	PF07714 PF00017 PF00018	7.2	Ki	ChEMBL
Q12851	MAP4K2	Homo sapiens	Human	PF00780 PF00069	7.2	Ki	ChEMBL
Q13188	STK3	Homo sapiens	Human	PF11629 PF00069	7.2	Ki	ChEMBL
P06493	CDK1	Homo sapiens	Human	PF00069	7.1	Ki	ChEMBL
Q9HBH9	MKNK2	Homo sapiens	Human	PF00069	7.0	Ki	ChEMBL
Q9H2G2	SLK	Homo sapiens	Human	PF00069 PF12474	6.9	Ki	ChEMBL
Q9Y4K4	MAP4K5	Homo sapiens	Human	PF00780 PF00069	6.9	Ki	ChEMBL
Q8N4C8	MINK1	Homo sapiens	Human	PF00780 PF00069	6.6	Ki	ChEMBL
P36888	FLT3	Homo sapiens	Human	PF00047 PF07714	6.4	Ki	ChEMBL
Q13131	PRKAA1	Homo sapiens	Human	PF16579 PF21147 PF00069	6.4	Ki	ChEMBL
P08581	MET	Homo sapiens	Human	PF07714 PF01437 PF01403 PF01833	6.3	Ki	ChEMBL
Q8NE63	HIPK4	Homo sapiens	Human	PF00069	6.3	Ki	ChEMBL
Q8TDC3	BRSK1	Homo sapiens	Human	PF21122 PF00069 PF21115	6.3	Ki	ChEMBL
P06239	LCK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.0	Ki	ChEMBL