InChIKey	HYIMSNHJOBLJNT-UHFFFAOYSA-N
Compound Name	Nifedipine
Canonical SMILES	COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-]
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	6
Pfam Stratification	Cross-Family
Avg pChEMBL	7.29
Source	ChEMBL;BindingDB

DrugBank ID	DB01115
Drug Name	Nifedipine
CAS Number	21829-25-4
Groups	approved investigational
ATC Codes	C08CA55 C08GA01 C08CA05 C07FB03
Description	Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifed...

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Categories: Agents causing hyperkalemia Antiarrhythmic agents Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates Beta blocking agents and calcium channel blockers Bradycardia-Causing Agents Calcium Channel Blockers Calcium Channel Blockers (Dihydropyridine) Calcium Channel Blockers and Diuretics Calcium-Regulating Hormones and Agents Cardiovascular Agents Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2A6 Substrates Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dihydropyridine Derivatives Dihydropyridines Drugs that are Mainly Renally Excreted Hypotensive Agents Membrane Transport Modulators Moderate Risk QTc-Prolonging Agents Negative Inotrope OATP1B1/SLCO1B1 Inhibitors P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Pyridines QTc Prolonging Agents Reproductive Control Agents Selective Calcium Channel Blockers With Mainly Vascular Effects Tocolytic Agents Vasodilating Agents

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Cross-references: BindingDB: 50101817 ChEBI: 7565 CHEMBL193 ChemSpider: 4330 Drugs Product Database (DPD): 1966 Guide to Pharmacology: 2514 IUPHAR: 2514 C07266 D00437 PDB: C5U PharmGKB: PA450631 PubChem:4485 PubChem:46505103 RxCUI: 7417 Therapeutic Targets Database: DAP000529 Wikipedia: Nifedipine ZINC: ZINC000085205448