Molecule Details
| InChIKey | HYAFETHFCAUJAY-UHFFFAOYSA-N |
|---|---|
| Compound Name | Pioglitazone |
| Canonical SMILES | CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.55 |
| Source | ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01132 |
|---|---|
| Drug Name | Pioglitazone |
| CAS Number | 111025-46-8 |
| Groups | approved investigational |
| ATC Codes | A10BD09 A10BG03 A10BD05 A10BD06 A10BD12 |
| Description | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear ... |
Categories: Alimentary Tract and Metabolism Blood Glucose Lowering Agents Cytochrome P-450 CYP1A1 Substrates Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs Used in Diabetes Hypoglycemia-Associated Agents OATP1B1/SLCO1B1 Inhibitors OATP1B3 inhibitors Oral Hypoglycemics Peroxisome Proliferator Receptor gamma Agonist Peroxisome Proliferator-activated Receptor Activity Sulfur Compounds Thiazoles Thiazolidinediones
Cross-references: BindingDB: 724000 ChEBI: 8228 CHEMBL595 ChemSpider: 4663 Drugs Product Database (DPD): 12012 Guide to Pharmacology: 2694 IUPHAR: 2694 C07675 D08378 PharmGKB: PA450970 PubChem:4829 PubChem:46507136 RxCUI: 33738 Therapeutic Targets Database: DAP000272 Wikipedia: Pioglitazone
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P00918 | CA2 | Homo sapiens | Human | PF00194 | 6.9 | IC50 | ChEMBL |
| P27338 | MAOB | Homo sapiens | Human | PF01593 | 6.5 | Ki | ChEMBL |
| O95342 | ABCB11 | Homo sapiens | Human | PF00664 PF00005 | 6.5 | IC50 | ChEMBL |
| Q9NZ45 | CISD1 | Homo sapiens | Human | PF10660 PF09360 | 6.4 | Ki | ChEMBL |
| P37231 | PPARG | Homo sapiens | Human | PF00104 PF12577 PF00105 | 6.4 | Ki | ChEMBL |
DrugBank Target Actions (10)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P02768 | ALB | Albumin | substrate | carriers |
| P08684 | CYP3A4 | Cytochrome P450 3A4 | inducer | enzymes |
| P10632 | CYP2C8 | Cytochrome P450 2C8 | inhibitor | enzymes |
| P04798 | CYP1A1 | Cytochrome P450 1A1 | substrate | enzymes |
| P08684 | CYP3A4 | Cytochrome P450 3A4 | substrate | enzymes |
| P10632 | CYP2C8 | Cytochrome P450 2C8 | substrate | enzymes |
| P37231 | PPARG | Peroxisome proliferator-activated receptor gamma | agonist | targets |
| P27338 | MAOB | Amine oxidase [flavin-containing] B | inhibitor | targets |
| Q9NPD5 | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | inhibitor | transporters |
| Q9Y6L6 | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | inhibitor | transporters |