Molecule Details
| InChIKey | HWZFQQYDALNGQT-UHFFFAOYSA-N |
|---|---|
| Compound Name | 6-(1-methyl-1H-pyrazol-4-yl)-N-(4-(trifluoromethoxy)phenyl)pyrimidin-4-amine |
| Canonical SMILES | Cn1cc(-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2)cn1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.16 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P00519 | ABL1 | Homo sapiens | Human | PF08919 PF07714 PF00017 PF00018 | 7.2 | Kd | ChEMBL;BindingDB |
| P11274 | BCR | Homo sapiens | Human | PF09036 PF00168 PF19057 PF00620 PF00621 | 7.2 | Kd | ChEMBL |
| A9UEZ6 | BCR/ABL fusion | Homo sapiens | Human | PF09036 PF08919 PF07714 PF00621 PF00017 | 7.0 | IC50 | BindingDB |