InChIKey	HWXVIOGONBBTBY-ONEGZZNKSA-N
Compound Name	Pacritinib
Canonical SMILES	C1=N/C2=N/c3ccc(OCCN4CCCC4)c(c3)COC/C=C/COCc3cccc(c3)C(=C1)N2
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	27
Pfam Stratification	Cross-Family
Avg pChEMBL	6.98
Source	ChEMBL;BindingDB

DrugBank ID	DB11697
Drug Name	Pacritinib
CAS Number	937272-79-2
Groups	approved investigational
ATC Codes	L01EJ03
Description	Myelofibrosis (MF) is a rare disorder characterized by hematopoietic abnormalities and fibrosis within the bone marrow.[L40793] The underlying cause of primary MF is unknown, but secondary MF can arise in patients with a history of polycythemia vera or essential thrombocythemia.[L40793] While some p...

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Categories: Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Inhibitors Cytochrome P-450 CYP1A2 Inducers Cytochrome P-450 CYP1A2 Inducers (strength unknown) Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Janus Kinase 2, antagonists & inhibitors Janus Kinase Inhibitor Janus Kinases, antagonists & inhibitors Kinase Inhibitor OCT1 inhibitors OCT2 Inhibitors P-glycoprotein inhibitors Potential QTc-Prolonging Agents Protein Kinase Inhibitors QTc Prolonging Agents Tyrosine Kinase Inhibitors fms-Like Tyrosine Kinase 3, antagonists & inhibitors

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Cross-references: BindingDB: 50210177 CHEMBL2035187 ChemSpider: 28518965 PDB: 6T3 PubChem:46216796 PubChem:347828062 RxCUI: 2595243 Wikipedia: Pacritinib ZINC: ZINC000043153645