Molecule Details
InChIKeyHWJPWWYTGBZDEG-UHFFFAOYSA-N
Compound NameIclaprim
Canonical SMILESCOc1cc(Cc2cnc(N)nc2N)c2c(c1OC)OC(C1CC1)C=C2
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL7.38
SourceChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB06358
Drug NameIclaprim
CAS Number192314-93-5
Groups investigational
ATC Codes J01EA03
Descriptionnan

Categories: Antibacterials for Systemic Use Antiinfectives for Systemic Use Enzyme Inhibitors Folic Acid Antagonists Sulfonamides and trimethoprim Trimethoprim and Derivatives
Cross-references: BindingDB: 18070 ChEBI: 131751 CHEMBL134561 ChemSpider: 184736 Wikipedia: Iclaprim
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P00374 DHFR Homo sapiens Human PF00186 6.1 Ki ChEMBL
P0A017 folA Staphylococcus aureus Pathogen PF00186 8.7 IC50 ChEMBL
DrugBank Target Actions (2)
Target Gene Target Name Action Type
P00374 DHFR Dihydrofolate reductase inhibitor targets
P0ABQ4 folA Dihydrofolate reductase modulator targets