Molecule Details
| InChIKey | HVDQYPSFEUUGDN-QGZVFWFLSA-N |
|---|---|
| Compound Name | (R)-7-Benzyl-2-bromo-5-ethyl-3-(4-hydroxy-benzyl)-7,8-dihydro-3H,5H-imidazo[2,1-b]purin-4-one |
| Canonical SMILES | CCN1C(=O)c2c(nc(Br)n2Cc2ccc(O)cc2)N2C[C@@H](Cc3ccccc3)N=C12 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 8 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.92 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (8)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O76074 | PDE5A | Homo sapiens | Human | PF01590 PF00233 | 8.6 | IC50 | ChEMBL;BindingDB |
| O43924 | PDE6D | Homo sapiens | Human | PF05351 | 6.8 | IC50 | ChEMBL |
| P16499 | PDE6A | Homo sapiens | Human | PF01590 PF00233 | 6.8 | IC50 | ChEMBL |
| P18545 | PDE6G | Homo sapiens | Human | PF04868 | 6.8 | IC50 | ChEMBL |
| P35913 | PDE6B | Homo sapiens | Human | PF01590 PF00233 | 6.8 | IC50 | ChEMBL |
| P51160 | PDE6C | Homo sapiens | Human | PF01590 PF00233 | 6.8 | IC50 | ChEMBL |
| Q13956 | PDE6H | Homo sapiens | Human | PF04868 | 6.8 | IC50 | ChEMBL |
| Q9HCR9 | PDE11A | Homo sapiens | Human | PF01590 PF00233 | 6.3 | IC50 | ChEMBL;BindingDB |