InChIKey	HUNGUWOZPQBXGX-UHFFFAOYSA-N
Compound Name	Tirbanibulin
Canonical SMILES	O=C(Cc1ccc(-c2ccc(OCCN3CCOCC3)cc2)cn1)NCc1ccccc1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	4
Pfam Stratification	Cross-Family
Avg pChEMBL	7.22
Source	ChEMBL;BindingDB

DrugBank ID	DB06137
Drug Name	Tirbanibulin
CAS Number	897016-82-9
Groups	approved investigational
ATC Codes	D06BX03
Description	Tirbanibulin (KX-O1 or KX2–391) is a dual inhibitor of Src Kinase and tubulin.[A225726] On December 14, 2020, tirbanibulin was approved by the FDA for the topical treatment of actinic keratosis on the face or scalp. It is marketed under the brand name Klisyri.[L27806] Actinic keratosis is a chronic ...

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Categories: Acetates Acids, Acyclic Amides Antineoplastic Agents Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (weak) Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (weak) Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (weak) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (weak) Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (weak) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Fatty Acids Fatty Acids, Volatile Keratosis, Actinic, drug therapy Kinase Inhibitor Lipids MATE 1 Inhibitors MATE 2 Inhibitors MATE inhibitors Microtubule Inhibitors OATP1B1/SLCO1B1 Inhibitors OATP1B3 inhibitors OCT1 inhibitors OCT2 Inhibitors Oxazines Tubulin Inhibiting Agent Tyrosine Kinase Inhibitors

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Cross-references: BindingDB: 50303801 CHEMBL571546 ChemSpider: 24633341 Drugs Product Database (DPD): 23842 PDB: DN0 RxCUI: 2471078 Wikipedia: Tirbanibulin ZINC: ZINC000043152787