Molecule Details
| InChIKey | HTQMVQVXFRQIKW-UHFFFAOYSA-N |
|---|---|
| Compound Name | Candesartan |
| Canonical SMILES | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 |
| Clinical Status | Clinical Multi-Target |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.08 |
| Source | BindingDB;ChEMBL;TTD_MultiTarget |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB13919 |
|---|---|
| Drug Name | Candesartan |
| CAS Number | 139481-59-7 |
| Groups | investigational |
| ATC Codes | C09DA06 C09DB07 C09DX06 C09CA06 C10BX19 |
| Description | Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is available as a prodrug in the form of [candesartan cilexetil]. |
Categories: Agents Acting on the Renin-Angiotensin System Agents causing hyperkalemia Angiotensin 2 Receptor Blocker Angiotensin II Type 2 Receptor Blockers Angiotensin II receptor antagonists Angiotensin II receptor blockers (ARBs) and calcium channel blockers Angiotensin II receptor blockers (ARBs) and diuretics Angiotensin II receptor blockers (ARBs), plain Angiotensin Receptor Antagonists Antihypertensive Agents Benzene Derivatives Cardiovascular Agents Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Inhibitors (weak) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (weak) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Heterocyclic Compounds, Fused-Ring Lipid Modifying Agents OATP1B1/SLCO1B1 Inhibitors P-glycoprotein inhibitors UGT1A3 substrates
Cross-references: BindingDB: 50240609 ChEBI: 3347 CHEMBL1016 ChemSpider: 2445 D00522 PharmGKB: PA448765 PubChem:2541 PubChem:347829334 RxCUI: 214354 Wikipedia: Candesartan ZINC: ZINC000003782818
Target Activities (3)
DrugBank Target Actions (8)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P10632 | CYP2C8 | Cytochrome P450 2C8 | inhibitor | enzymes |
| P11712 | CYP2C9 | Cytochrome P450 2C9 | inhibitor | enzymes |
| P11712 | CYP2C9 | Cytochrome P450 2C9 | substrate | enzymes |
| P23219 | PTGS1 | Prostaglandin G/H synthase 1 | substrate | enzymes |
| P35503 | P35503 | UDP-glucuronosyltransferase 1A3 | substrate | enzymes |
| P30556 | AGTR1 | Type-1 angiotensin II receptor | antagonist | targets |
| P08183 | ABCB1 | ATP-dependent translocase ABCB1 | inhibitor | transporters |
| Q9Y6L6 | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | inhibitor | transporters |