InChIKey	HSUGRBWQSSZJOP-RTWAWAEBSA-N
Compound Name	Diltiazem
Canonical SMILES	COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	5
Pfam Stratification	Cross-Family
Avg pChEMBL	6.42
Source	ChEMBL;BindingDB

DrugBank ID	DB00343
Drug Name	Diltiazem
CAS Number	42399-41-7
Groups	approved investigational
ATC Codes	C08DB01 C05AE03
Description	Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it primarily works by inhibiting the calcium inf...

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Categories: Agents causing hyperkalemia Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Antiarrhythmic agents Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension Benzazepines Benzothiazepine Derivatives Bradycardia-Causing Agents Calcium Channel Blockers Calcium Channel Blockers (Nondihydropyridine) Calcium-Regulating Hormones and Agents Cardiovascular Agents Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (moderate) Cytochrome P-450 CYP3A4 Inhibitors (strong) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Inhibitors (moderate) Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Inhibitors Cytochrome P-450 CYP3A7 Inhibitors (moderate) Cytochrome P-450 CYP3A7 Inhibitors (strong) Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs causing inadvertant photosensitivity Heterocyclic Compounds, Fused-Ring Hypotensive Agents Membrane Transport Modulators Miscellaneous Calcium-channel Blocking Agents Moderate Risk QTc-Prolonging Agents Negative Inotrope P-glycoprotein inhibitors P-glycoprotein substrates Photosensitizing Agents QTc Prolonging Agents Selective Calcium Channel Blockers With Direct Cardiac Effects Vasodilating Agents Vasoprotectives

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Cross-references: BindingDB: 50004704 ChEBI: 101278 CHEMBL23 ChemSpider: 35850 Drugs Product Database (DPD): 1926 C06958 D07845 PDB: C9F PharmGKB: PA449334 PubChem:39186 PubChem:46505667 RxCUI: 3443 Therapeutic Targets Database: DAP001262 Wikipedia: Diltiazem ZINC: ZINC000000621893