Molecule Details
InChIKeyHQVHOQAKMCMIIM-HXUWFJFHSA-N
Compound NameWin 55212-2
Canonical SMILESCc1c(C(=O)c2cccc3ccccc23)c2cccc3c2n1[C@H](CN1CCOCC1)CO3
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL7.85
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB13950
Drug NameWIN 55212-2
CAS Number131543-22-1
Groups experimental
ATC Codes nan
DescriptionWIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure. It is a potent cannabinoid receptor agonist that has been found to be a potent analgesi...

Categories: Agents causing hyperkalemia Agents producing tachycardia Analgesics Antiarrhythmic agents Bradycardia-Causing Agents Calcium Channel Blockers Calcium-Regulating Hormones and Agents Cannabinoid Receptor Antagonists Cannabinoids and similars Cardiovascular Agents Central Nervous System Agents Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Heterocyclic Compounds, Fused-Ring Membrane Transport Modulators Oxazines Peripheral Nervous System Agents Receptor, Cannabinoid, CB1, antagonists & inhibitors Sensory System Agents
Cross-references: BindingDB: 21281 ChEBI: 73295 CHEMBL188 ChemSpider: 4470978 PDB: WI5 Wikipedia: WIN_55,212-2 ZINC: ZINC000025783468
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P34972 CNR2 Homo sapiens Human PF00001 8.6 Ki ChEMBL;BindingDB
P21554 CNR1 Homo sapiens Human PF00001 7.7 Ki ChEMBL;BindingDB
A0A0V1DID4 CNRIP1 Trichinella britovi Pathogen PF15043 7.2 Ki BindingDB
DrugBank Target Actions (4)
Target Gene Target Name Action Type
P08684 CYP3A4 Cytochrome P450 3A4 inhibitor enzymes
P08684 CYP3A4 Cytochrome P450 3A4 substrate enzymes
P21554 CNR1 Cannabinoid receptor 1 inhibitor targets
P34972 CNR2 Cannabinoid receptor 2 inhibitor targets