Molecule Details
InChIKeyHQPNLIKXAPLWBQ-UHFFFAOYSA-N
Compound Name1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(4-fluoro-3-methylphenyl)urea
Canonical SMILESCc1cc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)ccc1F
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)12
Pfam Stratification Cross-Family
Avg pChEMBL7.88
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (12)
Target Gene Organism Category Pfam pChEMBL Type Source
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 10.1 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 9.4 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 9.0 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 8.4 IC50 ChEMBL;BindingDB
Q02161 RHD Homo sapiens Human PF00909 8.3 pIC50 TTD_MultiTarget
P36888 FLT3 Homo sapiens Human PF00047 PF07714 8.2 IC50 ChEMBL;BindingDB
P10721 KIT Homo sapiens Human PF00047 PF07714 8.0 IC50 ChEMBL;BindingDB
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.9 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.8 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.6 Ki ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.5 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.4 Ki ChEMBL