Molecule Details
| InChIKey | HPODOLXTMDHLLC-QGZVFWFLSA-N |
|---|---|
| Canonical SMILES | COc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCN(CC(F)(F)F)CC2)c2ccccc12 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.47 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB14581 |
|---|---|
| Drug Name | Lirametostat |
| CAS Number | 1621862-70-1 |
| Groups | investigational |
| ATC Codes | nan |
| Description | Potent and selective histone methyltransferase EZH2 inhibitor. |
Categories: Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring
Cross-references: ChemSpider: 58540498 ZINC: ZINC000220982768
Target Activities (2)
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| Q15910 | EZH2 | Histone-lysine N-methyltransferase EZH2 | inhibitor | targets |