Molecule Details
| InChIKey | HPMRFMKYPGXPEP-UHFFFAOYSA-N |
|---|---|
| Compound Name | Idazoxan |
| Canonical SMILES | c1ccc2c(c1)OCC(C1=NCCN1)O2 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 10 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.95 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB12551 |
|---|---|
| Drug Name | Idazoxan |
| CAS Number | 79944-58-4 |
| Groups | investigational |
| ATC Codes | nan |
| Description | Idazoxan has been used in trials studying the basic science of Molecular Imaging, Alzheimer Disease, and Major Depressive Disorder. |
Categories: Adrenergic Agents Adrenergic Antagonists Adrenergic alpha-2 Receptor Antagonists Adrenergic alpha-Antagonists Agents that produce hypertension Dioxanes Heterocyclic Compounds, Fused-Ring Imidazoles Neurotransmitter Agents
Cross-references: BindingDB: 50019848 ChEBI: 5862 CHEMBL10316 ChemSpider: 49184 C10968 PubChem:54459 PubChem:347828776 Wikipedia: Idazoxan
Target Activities (10)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P08913 | ADRA2A | Homo sapiens | Human | PF00001 | 8.1 | Ki | ChEMBL;BindingDB |
| P18825 | ADRA2C | Homo sapiens | Human | PF00001 | 7.7 | Ki | ChEMBL;BindingDB |
| P18089 | ADRA2B | Homo sapiens | Human | PF00001 | 7.6 | Ki | ChEMBL;BindingDB |
| Q9Y2I1 | NISCH | Homo sapiens | Human | PF25625 PF23142 PF00787 | 7.3 | Ki | ChEMBL;BindingDB |
| P25100 | ADRA1D | Homo sapiens | Human | PF00001 | 6.8 | Kd | ChEMBL |
| P35348 | ADRA1A | Homo sapiens | Human | PF00001 | 6.8 | Kd | ChEMBL |
| P35368 | ADRA1B | Homo sapiens | Human | PF00001 | 6.8 | Kd | ChEMBL |
| P08908 | HTR1A | Homo sapiens | Human | PF00001 | 6.2 | Ki | BindingDB |
| P21397 | MAOA | Homo sapiens | Human | PF01593 | 6.0 | IC50 | ChEMBL;BindingDB |
| P27338 | MAOB | Homo sapiens | Human | PF01593 | 6.0 | IC50 | ChEMBL;BindingDB |