Molecule Details
InChIKeyHNFMVVHMKGFCMB-UHFFFAOYSA-N
Compound NameMiransertib
Canonical SMILESNc1ncccc1-c1nc2ccc(-c3ccccc3)nc2n1-c1ccc(C2(N)CCC2)cc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL8.18
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB14982
Drug NameMiransertib
CAS Number1313881-70-7
Groups investigational
ATC Codes nan
DescriptionMiransertib is under investigation in clinical trial NCT01473095 (Phase 1 Dose Escalation Study of ARQ 092 in Adult Subjects With Advanced Solid Tumors and Recurrent Malignant Lymphoma).

Categories: Amines Pyridines
Cross-references: CHEMBL4297188 ChemSpider: 57251282 PDB: 6S1 ZINC: ZINC000072315647
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P31751 AKT2 Homo sapiens Human PF00169 PF00069 PF00433 8.3 IC50 ChEMBL;BindingDB
P31749 AKT1 Homo sapiens Human PF00169 PF00069 PF00433 8.3 IC50 ChEMBL;BindingDB
Q9Y243 AKT3 Homo sapiens Human PF00169 PF00069 PF00433 7.9 IC50 ChEMBL;BindingDB
DrugBank Target Actions (2)
Target Gene Target Name Action Type
P31749 AKT1 RAC-alpha serine/threonine-protein kinase inhibitor targets
Q9Y243 AKT3 RAC-gamma serine/threonine-protein kinase modulator targets