4-[5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-2-fluoro-pyridin-3-yl]-benzonitrile

Molecule Details

InChIKey	`HMZQULPVMKITSP-UHFFFAOYSA-N`
Compound Name	4-[5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-2-fluoro-pyridin-3-yl]-benzonitrile
Canonical SMILES	`N#Cc1ccc(-c2cc(C3CC4CCC3N4)cnc2F)cc1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Homologous
Avg pChEMBL	9.72
Source	ChEMBL;BindingDB

2D Structure

Activity Profile

DrugBank Annotations

DrugBank ID	DB14029
Drug Name	Furafylline
CAS Number	80288-49-9
Groups	experimental
ATC Codes	nan
Description	Furafylline is a derivative of methylxanthine derivative. It was developed on the context of asthma as a long-acting alternative for [theophylline].

Categories: Alkaloids Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strong) Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Purines Purinones Xanthine derivatives

Cross-references: BindingDB: 50171007 CHEMBL372638 ChemSpider: 23262468 Wikipedia: Furafylline

Target Activities (2)

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P17787	CHRNB2	Homo sapiens	Human	PF02931 PF02932	9.7	Ki	ChEMBL
P43681	CHRNA4	Homo sapiens	Human	PF02931 PF02932	9.7	Ki	ChEMBL

DrugBank Target Actions (1)

Target	Gene	Target Name	Action	Type
P05177	CYP1A2	Cytochrome P450 1A2	inhibitor	enzymes