Molecule Details
| InChIKey | HKZAFPHDQNGLOJ-UHFFFAOYSA-N |
|---|---|
| Compound Name | 2-bromo-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-methyl-5-[1-[4-(3,3,3-trifluoropropyl)piperazin-1-yl]ethyl]indolizine-7-carboxamide |
| Canonical SMILES | Cc1cc(C)c(CNC(=O)c2cc3cc(Br)cn3c(C(C)N3CCN(CCC(F)(F)F)CC3)c2C)c(=O)[nH]1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.26 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O75530 | EED | Homo sapiens | Human | PF00400 | 6.3 | IC50 | ChEMBL |
| Q09028 | RBBP4 | Homo sapiens | Human | PF12265 PF00400 | 6.3 | IC50 | ChEMBL |
| Q15022 | SUZ12 | Homo sapiens | Human | PF09733 PF23320 | 6.3 | IC50 | ChEMBL |
| Q15910 | EZH2 | Homo sapiens | Human | PF21358 PF11616 PF18118 PF18264 PF00856 | 6.3 | IC50 | ChEMBL;BindingDB |
| Q6ZN18 | AEBP2 | Homo sapiens | Human | PF26014 | 6.3 | IC50 | ChEMBL |