Molecule Details
| InChIKey | HKTBYUWLRDZAJK-UHFFFAOYSA-N |
|---|---|
| Compound Name | Tomivosertib |
| Canonical SMILES | Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.75 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB15219 |
|---|---|
| Drug Name | Tomivosertib |
| CAS Number | 1849590-01-7 |
| Groups | investigational |
| ATC Codes | nan |
| Description | Tomivosertib is under investigation in clinical trial NCT03318562 (A PD Study of Oral eFT508 in Subjects With Advanced TNBC and HCC). |
Cross-references: BindingDB: 50263263 CHEMBL4073443 ChemSpider: 57617704 PDB: N45 ZINC: ZINC000575623807
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q9HBH9 | MKNK2 | Homo sapiens | Human | PF00069 | 9.0 | IC50 | ChEMBL;BindingDB |
| Q9BUB5 | MKNK1 | Homo sapiens | Human | PF00069 | 8.6 | IC50 | ChEMBL;BindingDB |
| P06730 | EIF4E | Homo sapiens | Human | PF01652 | 8.3 | IC50 | ChEMBL |
| Q9UEE5 | STK17A | Homo sapiens | Human | PF00069 | 6.9 | IC50 | ChEMBL;BindingDB |
| Q9HAZ1 | CLK4 | Homo sapiens | Human | PF00069 | 6.1 | IC50 | ChEMBL;BindingDB |