Molecule Details
InChIKeyHKSZLNNOFSGOKW-HMWZOHBLSA-N
Compound Name(-)-Staurosporine
Canonical SMILESCN[C@H]1C[C@@H]2O[C@](C)([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)213
Pfam Stratification Cross-Family
Avg pChEMBL7.63
SourceBindingDB
2D Structure
2D structure
Activity Profile
Target Activities (213)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 10.7 Kd BindingDB
Q8N5S9 CAMKK1 Homo sapiens Human PF00069 10.4 Kd BindingDB
Q9H093 NUAK2 Homo sapiens Human PF00069 10.1 Kd BindingDB
P15735 PHKG2 Homo sapiens Human PF00069 9.8 Kd BindingDB
Q96RR4 CAMKK2 Homo sapiens Human PF00069 9.8 Kd BindingDB
Q9UQM7 CAMK2A Homo sapiens Human PF08332 PF00069 9.8 Kd BindingDB
Q13188 STK3 Homo sapiens Human PF11629 PF00069 9.7 Kd BindingDB
Q13043 STK4 Homo sapiens Human PF11629 PF00069 9.7 Kd BindingDB
Q02156 PRKCE Homo sapiens Human PF00130 PF00168 PF00069 PF00433 9.6 Kd BindingDB
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 9.5 Kd BindingDB
Q86V86 PIM3 Homo sapiens Human PF00069 9.3 Kd BindingDB
Q13555 CAMK2G Homo sapiens Human PF08332 PF00069 9.3 Kd BindingDB
Q13153 PAK1 Homo sapiens Human PF00786 PF00069 9.2 Kd BindingDB
Q9NQU5 PAK6 Homo sapiens Human PF00786 PF00069 9.2 Kd BindingDB
Q16816 PHKG1 Homo sapiens Human PF00069 9.2 Kd BindingDB
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 9.2 Kd BindingDB
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 9.1 Kd BindingDB
O43293 DAPK3 Homo sapiens Human PF00069 9.0 Kd BindingDB
Q8IU85 CAMK1D Homo sapiens Human PF00069 9.0 Kd BindingDB
Q9H0K1 SIK2 Homo sapiens Human PF00069 PF23312 9.0 Kd BindingDB
Q2M2I8 AAK1 Homo sapiens Human PF00069 8.9 Kd BindingDB
Q9P286 PAK5 Homo sapiens Human PF00786 PF00069 8.9 Kd BindingDB
Q13554 CAMK2B Homo sapiens Human PF08332 PF00069 8.9 Kd BindingDB
Q16512 PKN1 Homo sapiens Human PF02185 PF00069 PF00433 8.9 Kd BindingDB
P53355 DAPK1 Homo sapiens Human PF00023 PF12796 PF13637 PF00531 PF00069 8.8 Kd BindingDB
Q05655 PRKCD Homo sapiens Human PF00130 PF21494 PF00069 PF00433 8.8 Kd BindingDB
Q9UIK4 DAPK2 Homo sapiens Human PF00069 8.8 Kd BindingDB
O15530 PDPK1 Homo sapiens Human PF14593 PF00069 8.8 Kd BindingDB
P09619 PDGFRB Homo sapiens Human PF00047 PF13927 PF25305 PF07714 8.7 Kd BindingDB
Q9BYT3 STK33 Homo sapiens Human PF00069 8.7 Kd BindingDB
Q9P1W9 PIM2 Homo sapiens Human PF00069 8.7 Kd BindingDB
P57059 SIK1 Homo sapiens Human PF00069 PF23312 8.7 Kd BindingDB
P36888 FLT3 Homo sapiens Human PF00047 PF07714 8.7 Kd BindingDB
Q13470 TNK1 Homo sapiens Human PF07714 PF22931 8.6 Kd BindingDB
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 8.6 Kd BindingDB
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 8.5 Kd BindingDB
Q13177 PAK2 Homo sapiens Human PF00786 PF00069 8.5 Kd BindingDB
O14757 CHEK1 Homo sapiens Human PF00069 8.5 Kd BindingDB
P11309 PIM1 Homo sapiens Human PF00069 8.5 Kd BindingDB
P52564 MAP2K6 Homo sapiens Human PF00069 8.5 Kd BindingDB
Q09013 DMPK Homo sapiens Human PF08826 PF00069 8.5 Kd BindingDB
Q14289 PTK2B Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 8.5 Kd BindingDB
Q8IWQ3 BRSK2 Homo sapiens Human PF21122 PF00069 PF21115 8.5 Kd BindingDB
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 8.4 Kd BindingDB
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 8.4 Kd BindingDB
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 8.4 Kd BindingDB
Q9P0L2 MARK1 Homo sapiens Human PF02149 PF00069 PF00627 8.4 Kd BindingDB
Q92918 MAP4K1 Homo sapiens Human PF00780 PF00069 8.4 Kd BindingDB
O60285 NUAK1 Homo sapiens Human PF00069 8.4 Kd BindingDB
Q9UKE5 TNIK Homo sapiens Human PF00780 PF00069 8.3 Kd BindingDB
Q14164 IKBKE Homo sapiens Human PF00069 PF18394 PF18396 8.3 Kd BindingDB
Q08345 DDR1 Homo sapiens Human PF21114 PF00754 PF07714 8.3 IC50 BindingDB
Q96L34 MARK4 Homo sapiens Human PF02149 PF00069 PF00627 8.3 Kd BindingDB
Q96SB4 SRPK1 Homo sapiens Human PF00069 8.3 Kd BindingDB
Q9NSY1 BMP2K Homo sapiens Human PF15282 PF00069 8.2 Kd BindingDB
O96013 PAK4 Homo sapiens Human PF00786 PF00069 8.2 Kd BindingDB
P19784 CSNK2A2 Homo sapiens Human PF00069 8.2 Kd BindingDB
Q12866 MERTK Homo sapiens Human PF00041 PF00047 PF13927 PF07714 8.2 Kd BindingDB
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 8.2 Kd BindingDB
O75914 PAK3 Homo sapiens Human PF00786 PF00069 8.2 Kd BindingDB
P24941 CDK2 Homo sapiens Human PF00069 8.2 Kd BindingDB
P49760 CLK2 Homo sapiens Human PF00069 8.1 Kd BindingDB
Q8IVH8 MAP4K3 Homo sapiens Human PF00780 PF00069 8.1 Kd BindingDB
Q04759 PRKCQ Homo sapiens Human PF00130 PF21494 PF00069 PF00433 8.1 Kd BindingDB
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 8.0 IC50 BindingDB
Q9HAZ1 CLK4 Homo sapiens Human PF00069 8.0 Kd BindingDB
P16234 PDGFRA Homo sapiens Human PF07679 PF25305 PF07714 8.0 Kd BindingDB
P80192 MAP3K9 Homo sapiens Human PF07714 PF14604 8.0 Kd BindingDB
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 7.9 Kd BindingDB
P54646 PRKAA2 Homo sapiens Human PF16579 PF21147 PF00069 7.9 Kd BindingDB
P43405 SYK Homo sapiens Human PF07714 PF00017 7.8 Kd BindingDB
Q9UEE5 STK17A Homo sapiens Human PF00069 7.8 Kd BindingDB
Q15746 MYLK Homo sapiens Human PF16620 PF00041 PF07679 PF00069 7.8 Kd BindingDB
Q07912 TNK2 Homo sapiens Human PF09027 PF11555 PF07714 PF22931 PF14604 7.8 Kd BindingDB
Q86UE8 TLK2 Homo sapiens Human PF00069 7.8 Kd BindingDB
O14976 GAK Homo sapiens Human PF00069 PF10409 7.8 Kd BindingDB
P09769 FGR Homo sapiens Human PF07714 PF00017 PF00018 7.8 Kd BindingDB
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 7.8 Kd BindingDB
Q9C098 DCLK3 Homo sapiens Human PF00069 7.8 Kd BindingDB
Q9HBH9 MKNK2 Homo sapiens Human PF00069 7.8 Kd BindingDB
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 7.7 Kd BindingDB
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 7.7 Kd BindingDB
P17612 PRKACA Homo sapiens Human PF00069 7.7 Kd BindingDB
Q08881 ITK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 7.7 Kd BindingDB
Q96GD4 AURKB Homo sapiens Human PF00069 7.7 Kd BindingDB
P08631 HCK Homo sapiens Human PF07714 PF00017 PF00018 7.7 Kd BindingDB
Q16584 MAP3K11 Homo sapiens Human PF07714 PF14604 7.7 Kd BindingDB
O94768 STK17B Homo sapiens Human PF00069 7.7 Kd BindingDB
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.7 Kd BindingDB
Q02750 MAP2K1 Homo sapiens Human PF00069 7.7 Kd BindingDB
P07332 FES Homo sapiens Human PF00611 PF07714 PF00017 7.6 Kd BindingDB
Q96NX5 CAMK1G Homo sapiens Human PF00069 7.6 Kd BindingDB
Q9UQB9 AURKC Homo sapiens Human PF00069 7.6 Kd BindingDB
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 7.6 Kd BindingDB
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 7.6 Kd BindingDB
Q00536 CDK16 Homo sapiens Human PF00069 7.6 Kd BindingDB
Q9BXA7 TSSK1B Homo sapiens Human PF00069 7.6 Kd BindingDB
Q8TDC3 BRSK1 Homo sapiens Human PF21122 PF00069 PF21115 7.6 Kd BindingDB
P29320 EPHA3 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF07647 7.6 Kd BindingDB
Q14012 CAMK1 Homo sapiens Human PF00069 7.6 Kd BindingDB
Q15139 PRKD1 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 7.6 Kd BindingDB
Q9UKI8 TLK1 Homo sapiens Human PF00069 7.6 Kd BindingDB
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.5 Kd BindingDB
P36507 MAP2K2 Homo sapiens Human PF00069 7.5 Kd BindingDB
Q9Y2H1 STK38L Homo sapiens Human PF00069 PF00433 7.5 Kd BindingDB
Q9Y463 DYRK1B Homo sapiens Human PF00069 7.5 Kd BindingDB
P22694 PRKACB Homo sapiens Human PF00069 7.5 Kd BindingDB
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 7.5 Kd BindingDB
P08922 ROS1 Homo sapiens Human PF00041 PF07714 7.5 Kd BindingDB
Q00526 CDK3 Homo sapiens Human PF00069 7.5 Kd BindingDB
P49759 CLK1 Homo sapiens Human PF00069 7.5 Kd BindingDB
Q9UM73 ALK Homo sapiens Human PF12810 PF00629 PF07714 7.5 Kd BindingDB
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 7.5 Kd BindingDB
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 7.5 Kd BindingDB
Q8TD08 MAPK15 Homo sapiens Human PF00069 7.5 Kd BindingDB
P68400 CSNK2A1 Homo sapiens Human PF00069 7.4 Kd BindingDB
Q6DT37 CDC42BPG Homo sapiens Human PF00130 PF00780 PF08826 PF25346 PF00069 PF00433 7.4 Kd BindingDB
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 7.4 Kd BindingDB
Q16566 CAMK4 Homo sapiens Human PF00069 7.4 Kd BindingDB
O75582 RPS6KA5 Homo sapiens Human PF00069 PF00433 7.4 Kd BindingDB
O95835 LATS1 Homo sapiens Human PF00069 PF00433 PF00627 7.4 Kd BindingDB
P53778 MAPK12 Homo sapiens Human PF00069 7.4 Kd BindingDB
Q16832 DDR2 Homo sapiens Human PF21114 PF00754 PF07714 7.4 Kd BindingDB
Q9Y5S2 CDC42BPB Homo sapiens Human PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 7.4 Kd BindingDB
Q99755 PIP5K1A Homo sapiens Human PF01504 7.4 Kd BindingDB
P31751 AKT2 Homo sapiens Human PF00169 PF00069 PF00433 7.4 Kd BindingDB
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 7.3 Kd BindingDB
P50613 CDK7 Homo sapiens Human PF00069 7.3 Kd BindingDB
P07947 YES1 Homo sapiens Human PF07714 PF00017 PF00018 7.3 Kd BindingDB
Q02779 MAP3K10 Homo sapiens Human PF07714 PF14604 7.3 Kd BindingDB
Q5VT25 CDC42BPA Homo sapiens Human PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 PF00433 7.2 Kd BindingDB
P33981 TTK Homo sapiens Human PF00069 7.2 Kd BindingDB
Q15831 STK11 Homo sapiens Human PF00069 7.2 Kd BindingDB
Q9H1R3 MYLK2 Homo sapiens Human PF00069 7.2 Kd BindingDB
P35590 TIE1 Homo sapiens Human PF00041 PF00047 PF07714 7.2 Kd BindingDB
Q05397 PTK2 Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 7.2 Kd BindingDB
P78362 SRPK2 Homo sapiens Human PF00069 7.2 Kd BindingDB
P49841 GSK3B Homo sapiens Human PF00069 7.2 Kd BindingDB
P45985 MAP2K4 Homo sapiens Human PF00069 7.2 Kd BindingDB
P49674 CSNK1E Homo sapiens Human PF00069 7.1 Kd BindingDB
Q8N568 DCLK2 Homo sapiens Human PF03607 PF00069 7.1 Kd BindingDB
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 7.1 Kd BindingDB
O14730 RIOK3 Homo sapiens Human PF01163 7.1 Kd BindingDB
P78356 PIP4K2B Homo sapiens Human PF01504 7.1 Kd BindingDB
Q15391 P2RY14 Homo sapiens Human PF00001 7.1 Kd BindingDB
Q00535 CDK5 Homo sapiens Human PF00069 7.1 Kd BindingDB
O15146 MUSK Homo sapiens Human PF01392 PF07679 PF13927 PF07714 7.1 Kd BindingDB
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 7.1 Kd BindingDB
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 7.0 Kd BindingDB
P54756 EPHA5 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 7.0 Kd BindingDB
Q00537 CDK17 Homo sapiens Human PF00069 7.0 Kd BindingDB
Q9NY57 STK32B Homo sapiens Human PF00069 7.0 Kd BindingDB
P21802 FGFR2 Homo sapiens Human PF07679 PF13927 PF07714 7.0 Kd BindingDB
P50750 CDK9 Homo sapiens Human PF00069 7.0 Kd BindingDB
O00506 STK25 Homo sapiens Human PF20929 PF00069 7.0 Kd BindingDB
O14965 AURKA Homo sapiens Human PF00069 7.0 Kd BindingDB
O15075 DCLK1 Homo sapiens Human PF03607 PF00069 7.0 Kd BindingDB
P06213 INSR Homo sapiens Human PF00757 PF17870 PF07714 PF01030 7.0 Kd BindingDB
P42684 ABL2 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 7.0 Kd BindingDB
P53779 MAPK10 Homo sapiens Human PF00069 7.0 Kd BindingDB
O75676 RPS6KA4 Homo sapiens Human PF00069 PF00433 6.9 Kd BindingDB
Q9Y6E0 STK24 Homo sapiens Human PF20929 PF00069 6.9 Kd BindingDB
Q9BRS2 RIOK1 Homo sapiens Human PF01163 6.9 Kd BindingDB
P49840 GSK3A Homo sapiens Human PF00069 6.8 Kd BindingDB
Q02763 TEK Homo sapiens Human PF00041 PF10430 PF07714 6.8 Kd BindingDB
Q32MK0 MYLK3 Homo sapiens Human PF00069 6.8 Kd BindingDB
Q9P289 STK26 Homo sapiens Human PF20929 PF00069 6.8 Kd BindingDB
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.8 Kd BindingDB
O94921 CDK14 Homo sapiens Human PF00069 6.8 Kd BindingDB
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 6.8 Kd BindingDB
P51813 BMX Homo sapiens Human PF00779 PF00169 PF07714 PF00017 6.8 Kd BindingDB
Q9BUB5 MKNK1 Homo sapiens Human PF00069 6.8 Kd BindingDB
Q9Y243 AKT3 Homo sapiens Human PF00169 PF00069 PF00433 6.8 Kd BindingDB
P08581 MET Homo sapiens Human PF07714 PF01437 PF01403 PF01833 6.7 Kd BindingDB
P29322 EPHA8 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 6.7 Kd BindingDB
Q9BWU1 CDK19 Homo sapiens Human PF00069 6.7 Kd BindingDB
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.7 Kd BindingDB
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.7 Kd BindingDB
P45983 MAPK8 Homo sapiens Human PF00069 6.7 Kd BindingDB
Q9UBE8 NLK Homo sapiens Human PF00069 6.7 Kd BindingDB
P42681 TXK Homo sapiens Human PF07714 PF00017 PF00018 6.6 Kd BindingDB
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.6 Kd BindingDB
P54762 EPHB1 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 6.6 Kd BindingDB
P22455 FGFR4 Homo sapiens Human PF07679 PF13927 PF07714 6.6 Kd BindingDB
Q8N752 CSNK1A1L Homo sapiens Human PF00069 6.6 Kd BindingDB
O75716 STK16 Homo sapiens Human PF00069 6.6 Kd BindingDB
Q07002 CDK18 Homo sapiens Human PF00069 6.6 Kd BindingDB
Q8NFD2 ANKK1 Homo sapiens Human PF00023 PF12796 PF13637 PF07714 6.6 Kd BindingDB
Q06418 TYRO3 Homo sapiens Human PF00041 PF07679 PF07714 6.5 Kd BindingDB
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.5 Kd BindingDB
P54764 EPHA4 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF07647 6.5 Kd BindingDB
P21709 EPHA1 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 6.5 Kd BindingDB
Q8WXR4 MYO3B Homo sapiens Human PF00612 PF00063 PF00069 6.5 Kd BindingDB
Q15569 TESK1 Homo sapiens Human PF07714 6.5 Kd BindingDB
P41240 CSK Homo sapiens Human PF07714 PF00017 PF00018 6.5 Kd BindingDB
O14578 CIT Homo sapiens Human PF00780 PF00169 PF00069 PF00433 6.5 Kd BindingDB
P19525 EIF2AK2 Homo sapiens Human PF00035 PF00069 6.4 Kd BindingDB
Q15375 EPHA7 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 6.4 Kd BindingDB
Q04771 ACVR1 Homo sapiens Human PF01064 PF07714 PF08515 6.3 Kd BindingDB
Q86YV6 MYLK4 Homo sapiens Human PF00069 6.3 Kd BindingDB
P53667 LIMK1 Homo sapiens Human PF00412 PF00595 PF07714 6.3 Kd BindingDB
Q8NEV4 MYO3A Homo sapiens Human PF00612 PF00063 PF00069 6.3 Kd BindingDB
P49336 CDK8 Homo sapiens Human PF00069 6.3 Kd BindingDB
P10721 KIT Homo sapiens Human PF00047 PF07714 6.2 Ki BindingDB
P36896 ACVR1B Homo sapiens Human PF01064 PF00069 PF08515 6.2 Kd BindingDB
Q9H3Y6 SRMS Homo sapiens Human PF07714 PF00017 6.1 Kd BindingDB
P51955 NEK2 Homo sapiens Human PF00069 6.1 Kd BindingDB
P78368 CSNK1G2 Homo sapiens Human PF12605 PF00069 6.1 Kd BindingDB
Q15303 ERBB4 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.1 Kd BindingDB
Q6P3R8 NEK5 Homo sapiens Human PF00069 6.1 Kd BindingDB
P49761 CLK3 Homo sapiens Human PF00069 6.0 Kd BindingDB
Q9H4B4 PLK3 Homo sapiens Human PF00069 PF00659 6.0 Kd BindingDB
Q59H18 TNNI3K Homo sapiens Human PF12796 PF07714 6.0 Kd BindingDB