Molecule Details
| InChIKey | HJORMJIFDVBMOB-UHFFFAOYSA-N |
|---|---|
| Compound Name | Rolipram |
| Canonical SMILES | COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 6 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.5 |
| Source | ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01954 |
|---|---|
| Drug Name | Rolipram |
| CAS Number | 61413-54-5 |
| Groups | investigational |
| ATC Codes | nan |
| Description | A phosphodiesterase inhibitor with antidepressant properties. |
Categories: Antidepressive Agents Central Nervous System Agents Central Nervous System Depressants Enzyme Inhibitors Phosphodiesterase 4 Inhibitors Phosphodiesterase Inhibitors Psychotropic Drugs Pyrrolidines Pyrrolidinones
Cross-references: BindingDB: 50639239 ChEBI: 104872 CHEMBL63 ChemSpider: 4913 D01783 PharmGKB: PA153906323 PubChem:5092 PubChem:46508075 Wikipedia: Rolipram
Target Activities (6)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P27815 | PDE4A | Homo sapiens | Human | PF18100 PF00233 | 6.7 | IC50 | ChEMBL |
| Q07343 | PDE4B | Homo sapiens | Human | PF18100 PF00233 | 6.7 | IC50 | ChEMBL |
| Q08493 | PDE4C | Homo sapiens | Human | PF18100 PF00233 | 6.7 | IC50 | ChEMBL |
| Q08499 | PDE4D | Homo sapiens | Human | PF18100 PF00233 | 6.5 | IC50 | ChEMBL |
| P01375 | TNF | Homo sapiens | Human | PF00229 | 6.3 | IC50 | ChEMBL |
| O76074 | PDE5A | Homo sapiens | Human | PF01590 PF00233 | 6.1 | IC50 | ChEMBL |
DrugBank Target Actions (4)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| O76074 | PDE5A | cGMP-specific 3',5'-cyclic phosphodiesterase | inhibitor | targets |
| P27815 | PDE4A | cAMP-specific 3',5'-cyclic phosphodiesterase 4 (PDE4) | inhibitor | targets |
| Q07343 | PDE4B | 3',5'-cyclic-AMP phosphodiesterase 4B | inhibitor | targets |
| Q08499 | PDE4D | 3',5'-cyclic-AMP phosphodiesterase 4D | inhibitor | targets |