Molecule Details
| InChIKey | HJMQDJPMQIHLPB-UHFFFAOYSA-N |
|---|---|
| Compound Name | Zardaverine |
| Canonical SMILES | COc1cc(-c2ccc(=O)[nH]n2)ccc1OC(F)F |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 6 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.55 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB02918 |
|---|---|
| Drug Name | Zardaverine |
| CAS Number | 101975-10-4 |
| Groups | experimental |
| ATC Codes | nan |
| Description | nan |
Categories: Anti-Asthmatic Agents Autonomic Agents Bronchodilator Agents Enzyme Inhibitors Peripheral Nervous System Agents Phosphodiesterase Inhibitors Respiratory System Agents
Cross-references: BindingDB: 14769 ChEBI: 46548 CHEMBL313842 ChemSpider: 5521 PDB: ZAR PubChem:5723 PubChem:46506162 Wikipedia: Zardaverine ZINC: ZINC000009230249
Target Activities (6)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P27815 | PDE4A | Homo sapiens | Human | PF18100 PF00233 | 6.8 | IC50 | ChEMBL |
| Q07343 | PDE4B | Homo sapiens | Human | PF18100 PF00233 | 6.8 | IC50 | ChEMBL;BindingDB |
| Q08493 | PDE4C | Homo sapiens | Human | PF18100 PF00233 | 6.8 | IC50 | ChEMBL |
| Q08499 | PDE4D | Homo sapiens | Human | PF18100 PF00233 | 6.4 | IC50 | ChEMBL;BindingDB |
| Q13370 | PDE3B | Homo sapiens | Human | PF00233 | 6.2 | IC50 | ChEMBL |
| Q14432 | PDE3A | Homo sapiens | Human | PF00233 | 6.2 | IC50 | ChEMBL;BindingDB |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| Q08499 | PDE4D | 3',5'-cyclic-AMP phosphodiesterase 4D | binder | targets |