Molecule Details
InChIKeyHIFJCPQKFCZDDL-ACWOEMLNSA-N
Compound NameIloprost
Canonical SMILESCC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)5
Pfam Stratification Homologous
Avg pChEMBL7.2
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB01088
Drug NameIloprost
CAS Number78919-13-8
Groups approved investigational
ATC Codes B01AC11
DescriptionIloprost is an analog of prostacyclin (PGI2; epoprostenol), an endogenous prostanoid mainly produced in the vascular endothelium. It is more stable than prostacyclin, which is short-lived.[A263326] Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47.[L5...

Categories: Agents Causing Muscle Toxicity Antiplatelet agents Autacoids Biological Factors Blood and Blood Forming Organs Cardiovascular Agents Eicosanoids Fatty Acids Fatty Acids, Unsaturated Hematologic Agents Hypotensive Agents Inflammation Mediators Lipids OATP2B1/SLCO2B1 substrates Platelet Aggregation Inhibitors Excl. Heparin Prostacyclin Analogues Prostaglandins Prostaglandins, Synthetic Vasodilating Agents
Cross-references: BindingDB: 23954 ChEBI: 63916 CHEMBL494 ChemSpider: 4470703 PharmGKB: PA164746843 PubChem:5311181 PubChem:46507818 RxCUI: 40138 Therapeutic Targets Database: DAP000273 Wikipedia: Iloprost
Target Activities (5)
Target Gene Organism Category Pfam pChEMBL Type Source
P43119 PTGIR Homo sapiens Human PF00001 8.1 IC50 ChEMBL;BindingDB
P34995 PTGER1 Homo sapiens Human PF00001 8.0 Ki BindingDB
P43115 PTGER3 Homo sapiens Human PF00001 7.2 Ki BindingDB
P35408 PTGER4 Homo sapiens Human PF00001 6.5 Ki BindingDB
P43088 PTGFR Homo sapiens Human PF00001 6.2 Ki BindingDB
DrugBank Target Actions (13)
Target Gene Target Name Action Type
P02768 ALB Albumin binder carriers
P34995 PTGER1 Prostaglandin E2 receptor EP1 subtype agonist targets
P43116 PTGER2 Prostaglandin E2 receptor EP2 subtype agonist targets
P43119 PTGIR Prostacyclin receptor agonist targets
Q9Y5Y4 PTGDR2 Prostaglandin D2 receptor 2 agonist targets
P27815 PDE4A 3',5'-cyclic-AMP phosphodiesterase 4A inducer targets
Q07343 PDE4B 3',5'-cyclic-AMP phosphodiesterase 4B inducer targets
Q08493 PDE4C 3',5'-cyclic-AMP phosphodiesterase 4C inducer targets
Q08499 PDE4D 3',5'-cyclic-AMP phosphodiesterase 4D inducer targets
P00750 PLAT Tissue-type plasminogen activator other/unknown targets
O94956 SLCO2B1 Solute carrier organic anion transporter family member 2B1 substrate transporters
Q92959 SLCO2A1 Solute carrier organic anion transporter family member 2A1 substrate transporters
Q9UIG8 Q9UIG8 Solute carrier organic anion transporter family member 3A1 substrate transporters