Molecule Details
InChIKeyHHCBMISMPSAZBF-UHFFFAOYSA-N
Compound NameLy-3009120
Canonical SMILESCNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(C)nc2n1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)23
Pfam Stratification Cross-Family
Avg pChEMBL6.91
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (23)
Target Gene Organism Category Pfam pChEMBL Type Source
P04049 RAF1 Homo sapiens Human PF00130 PF07714 PF02196 8.4 IC50 ChEMBL;BindingDB
P15056 BRAF Homo sapiens Human PF00130 PF07714 PF02196 7.9 IC50 ChEMBL;BindingDB
P29317 EPHA2 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 7.7 IC50 ChEMBL;BindingDB
Q9NYL2 MAP3K20 Homo sapiens Human PF07714 PF07647 7.4 IC50 ChEMBL;BindingDB
P10398 ARAF Homo sapiens Human PF00130 PF07714 PF02196 7.4 IC50 ChEMBL;BindingDB
O15264 MAPK13 Homo sapiens Human PF00069 7.2 IC50 ChEMBL
P53778 MAPK12 Homo sapiens Human PF00069 7.2 IC50 ChEMBL
Q15759 MAPK11 Homo sapiens Human PF00069 7.2 IC50 ChEMBL
Q16539 MAPK14 Homo sapiens Human PF00069 7.2 IC50 ChEMBL;BindingDB
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 7.0 IC50 ChEMBL;BindingDB
Q13233 MAP3K1 Homo sapiens Human PF21040 PF00069 PF04434 7.0 IC50 ChEMBL;BindingDB
P54760 EPHB4 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 7.0 IC50 ChEMBL;BindingDB
P01116 KRAS Homo sapiens Human PF00071 6.8 IC50 ChEMBL
P41240 CSK Homo sapiens Human PF07714 PF00017 PF00018 6.5 IC50 ChEMBL;BindingDB
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.5 IC50 ChEMBL;BindingDB
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.4 IC50 ChEMBL;BindingDB
P51617 IRAK1 Homo sapiens Human PF00531 PF00069 6.4 IC50 ChEMBL;BindingDB
Q9P2K8 EIF2AK4 Homo sapiens Human PF12745 PF00069 PF05773 PF13393 6.3 IC50 ChEMBL;BindingDB
P45983 MAPK8 Homo sapiens Human PF00069 6.3 IC50 ChEMBL
P45984 MAPK9 Homo sapiens Human PF00069 6.3 IC50 ChEMBL
P53779 MAPK10 Homo sapiens Human PF00069 6.3 IC50 ChEMBL
Q13163 MAP2K5 Homo sapiens Human PF00564 PF00069 6.1 IC50 ChEMBL;BindingDB
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.0 IC50 ChEMBL;BindingDB