Molecule Details
InChIKeyHGLWPJISHDLCTE-UHFFFAOYSA-N
Compound NameN-[5-(4-cyanothiophen-2-yl)-1H-pyrazol-3-yl]-4-[(1-methylpiperidin-4-yl)amino]benzamide
Canonical SMILESCN1CCC(Nc2ccc(C(=O)Nc3cc(-c4cc(C#N)cs4)n[nH]3)cc2)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)7
Pfam Stratification Cross-Family
Avg pChEMBL6.8
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (7)
Target Gene Organism Category Pfam pChEMBL Type Source
P36888 FLT3 Homo sapiens Human PF00047 PF07714 8.5 IC50 ChEMBL;BindingDB
P10721 KIT Homo sapiens Human PF00047 PF07714 7.3 IC50 ChEMBL;BindingDB
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 7.3 IC50 ChEMBL;BindingDB
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.3 Kd ChEMBL;BindingDB
P11309 PIM1 Homo sapiens Human PF00069 6.1 IC50 ChEMBL;BindingDB
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 6.0 IC50 ChEMBL;BindingDB
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.0 IC50 ChEMBL;BindingDB