Molecule Details
| InChIKey | HGGAKXAHAYOLDJ-FHZUQPTBSA-N |
|---|---|
| Compound Name | Faropenem |
| Canonical SMILES | C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C([C@H]3CCCO3)S[C@H]12 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.1 |
| Source | BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB12190 |
|---|---|
| Drug Name | Faropenem |
| CAS Number | 106560-14-9 |
| Groups | investigational |
| ATC Codes | J01DI03 |
| Description | Faropenem has been used in trials studying the treatment of Tuberculosis, Pulmonary Tuberculosis, and Community Acquired Pneumonia. |
Categories: Amides Antibacterials for Systemic Use Antiinfectives for Systemic Use Heterocyclic Compounds, Fused-Ring Lactams Sulfur Compounds
Cross-references: ChEBI: 51257 CHEMBL556262 ChemSpider: 59303 PDB: FPM PubChem:65894 PubChem:347828475 Wikipedia: Faropenem ZINC: ZINC000003959242
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P0A3M5 | penA | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) | Pathogen | PF03717 PF00905 | 7.3 | IC50 | BindingDB |
| Q04707 | ponA | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) | Pathogen | PF00912 PF00905 | 7.3 | IC50 | BindingDB |
| P14677 | pbpX | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) | Pathogen | PF03793 PF03717 PF00905 | 6.7 | IC50 | BindingDB |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P0AC13 | P0AC13 | Dihydropteroate synthase | inhibitor | targets |